Glutathione and Nitric Oxide: Key Team Players in Use and Disuse of Skeletal Muscle Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes Journal of Hepatology Full article: The central role of glutathione in the pathophysiology of human diseases Summary. Depletion of glutathione (GSH) and increased ROS production Download Scientific Diagram Glutathione (GSH) Vs. NAD+ Both serve as powerhouse molecules, and are critically important for cellular health. They work together to create stronger, healthier, longer lived cells. Yet, they function differently within our