Acetaminophen and hepatotoxicity. Acetaminophen (paracetamol) is Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Frontiers Commentary: Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Glutathione Depletion in Mitochondrial Diseases Glutathione Reporter